Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats.

@article{Waalkes2000RepeatedCE,
  title={Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats.},
  author={Michael P. Waalkes and Sabine Rehm and M. George Cherian},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={54 1},
  pages={
          110-20
        }
}
Prior studies show that a single subcutaneous (sc) exposure to cadmium (Cd) will induce injection site sarcomas (ISS) in rats. These tumors, thought clearly malignant, do not often metastasize or invade subdermal muscle layers because of their location. Recent evidence indicates that when tumorigenic cells chronically exposed to Cd in vitro are inoculated into mice, tumor progression and invasiveness in the mice are enhanced. Thus, we studied the effects of repeated Cd exposures on tumor… CONTINUE READING
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