Repeated asphyxia causes loss of striatal projection neurons in the fetal sheep brain.

@article{Mallard1995RepeatedAC,
  title={Repeated asphyxia causes loss of striatal projection neurons in the fetal sheep brain.},
  author={E Carina Mallard and Henry John Waldvogel and Christopher Edward Williams and Richard Lewis Maxwell Faull and Peter Gluckman},
  journal={Neuroscience},
  year={1995},
  volume={65 3},
  pages={827-36}
}
Repeated episodes of cerebral hypoxia-ischemia can cause primarily striatal neuronal loss in the developing brain. We investigated the effect of repeated episodes of asphyxia on specific neuronal sub-populations of the basal ganglia in late-gestation fetal sheep. Asphyxia was induced in 10 fetal sheep (118-126 days gestation) by occluding the umbilical cord for 5 min. This procedure was repeated four times at 30 min intervals and the brains were fixed 3 days later for histopathology… CONTINUE READING
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