Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigs.

@article{Ishida1989RepeatedAC,
  title={Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigs.},
  author={Kiyoshi Ishida and Lori J Kelly and Robert J. Thomson and Lyn Beattie and R. Robert Schellenberg},
  journal={Journal of applied physiology},
  year={1989},
  volume={67 3},
  pages={
          1133-9
        }
}
  • Kiyoshi Ishida, Lori J Kelly, +2 authors R. Robert Schellenberg
  • Published 1989
  • Medicine
  • Journal of applied physiology
  • To test the hypothesis that the development of airway hyperresponsiveness (AHR) lasting greater than or equal to 3 days after the last antigenic exposure required repeated mediator release, we compared dose-response changes in lung resistance (RL) to acetylcholine (ACh) in animals sensitized with 1% ovalbumin (OA), 4% Bordatella pertussis aerosol and subsequently challenged with 0.5% OA aerosol twice weekly for 4-6 wk vs. animals receiving saline aerosol instead of OA. Despite antihistamine… CONTINUE READING

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