Repeated allergen exposure changes collagen composition in airways of sensitised Brown Norway rats.

@article{Palmans2002RepeatedAE,
  title={Repeated allergen exposure changes collagen composition in airways of sensitised Brown Norway rats.},
  author={Els Palmans and Romain A. Pauwels and Johan C. Kips},
  journal={The European respiratory journal},
  year={2002},
  volume={20 2},
  pages={280-5}
}
Increased or altered collagen deposition in the airway wall is one of the characteristics of airway remodelling in asthma. The mechanisms underlying this increase, and its functional consequences remain to be established further. Representative in vivo animal models might be useful in this respect. In the present study, collagen deposition after prolonged allergen exposure was characterised in the airway wall of Brown Norway rats. Sensitised rats were repeatedly exposed to ovalbumin (OA) or… CONTINUE READING

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