Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens.

@article{Fuentealba2006RepeatedAO,
  title={Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens.},
  author={Jos{\'e} Antonio Fuentealba and Katia Gysling and Karin Magendzo and Mar{\'i}a Estela Andr{\'e}s},
  journal={Journal of neuroscience research},
  year={2006},
  volume={84 2},
  pages={450-9}
}
Reinforcing properties of drugs of abuse are reduced by the coadministration of kappa opioid receptor (KOR) agonists. This effect is related to the inhibition of dopamine (DA) release in the nucleus accumbens (NAc) produced by the acute administration of KOR agonists. The present study was undertaken to investigate the in vivo effect of the repeated administration of KOR agonist on extracellular DA levels in the NAc. Rats were injected once daily with the selective KOR agonist U-69593 (0.16-0… CONTINUE READING

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