Repeated administration of phytocannabinoid Δ(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner.

@article{Tai2015RepeatedAO,
  title={Repeated administration of phytocannabinoid Δ(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner.},
  author={Sherrica Tai and William S Hyatt and Chunping Gu and Lirit N. Franks and Tamara Vasiljevik and Lisa K. Brents and Paul L. Prather and William E Fantegrossi},
  journal={Pharmacological research},
  year={2015},
  volume={102},
  pages={22-32}
}
These studies probed the relationship between intrinsic efficacy and tolerance/cross-tolerance between ∆(9)-THC and synthetic cannabinoid drugs of abuse (SCBs) by examining in vivo effects and cellular changes concomitant with their repeated administration in mice. Dose-effect relationships for hypothermic effects were determined in order to confirm that SCBs JWH-018 and JWH-073 are higher efficacy agonists than ∆(9)-THC in mice. Separate groups of mice were treated with saline, sub-maximal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice.

The Journal of pharmacology and experimental therapeutics • 2016
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…