Repeated administration of antidepressants decreases field potentials in rat frontal cortex.

@article{Bobula2003RepeatedAO,
  title={Repeated administration of antidepressants decreases field potentials in rat frontal cortex.},
  author={Bartosz Bobula and Krzysztof Tokarski and Grzegorz Hess},
  journal={Neuroscience},
  year={2003},
  volume={120 3},
  pages={765-9}
}
The effects of repeated administration of a tricyclic antidepressant, imipramine, and a selective serotonin reuptake blocker, citalopram, for 14 days (10 mg/kg p.o., twice daily), were studied ex vivo in rat frontal cortex slices prepared 48 h after last dose of the drug. Treatment with both antidepressants resulted in a decrease in the amplitude of field potentials evoked in layer II/III by stimulation of underlying sites in layer V. The amplitude ratio of pharmacologically isolated N-methyl-D… CONTINUE READING