Repeated administration of antidepressants enhances agonist affinity for mesolimbic D2-receptors.

@article{Klimek1989RepeatedAO,
  title={Repeated administration of antidepressants enhances agonist affinity for mesolimbic D2-receptors.},
  author={Violetta Klimek and Jerzy Maj},
  journal={The Journal of pharmacy and pharmacology},
  year={1989},
  volume={41 8},
  pages={555-8}
}
Studies have shown an increased responsiveness of the dopaminergic system after repeated administration of a variety of antidepressant drugs. In the present study, the effect of repeated administration (twice daily for 14 days) of imipramine and mianserin on the affinity of dopamine D2-receptors for quinpirole, a D2-agonist, and on the quinpirole-induced locomotor hyperactivity was examined in rats. Repeated doses of imipramine and mianserin increased the affinity of quinpirole for [3H… CONTINUE READING

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