Repeated administration of amphetamine induces sensitisation to its disruptive effect on prepulse inhibition in the rat

@article{Zhang1998RepeatedAO,
  title={Repeated administration of amphetamine induces sensitisation to its disruptive effect on prepulse inhibition in the rat},
  author={Jianhua Zhang and J{\"o}rgen A. Engel and Bo S{\"o}derpalm and Lennart Svensson},
  journal={Psychopharmacology},
  year={1998},
  volume={135},
  pages={401-406}
}
 Male Sprague-Dawley rats were repeatedly treated with amphetamine (AMP, 1 mg/kg, SC) at 3- day intervals for 15 days and tested for prepulse inhibition of acoustic startle after each treatment. This treatment regimen induced sensitisation in the animals as evidenced by a progressive increase in the disruptive effect of AMP on prepulse inhibition. Persistent changes in brain function was indicated, since an increase in disruptive effect was observed in sensitised animals also after a 22-day… CONTINUE READING