Repeated administration of SR 46349B, a selective 5-hydroxytryptamine2 antagonist, up-regulates 5-hydroxytryptamine2 receptors in mouse brain.

@article{RinaldiCarmona1993RepeatedAO,
  title={Repeated administration of SR 46349B, a selective 5-hydroxytryptamine2 antagonist, up-regulates 5-hydroxytryptamine2 receptors in mouse brain.},
  author={Murielle Rinaldi-Carmona and Christian Congy and Jacques Simiand and Florence Oury-Donat and Philippe Soubri{\'e} and J. C. Breli{\`e}re and G{\'e}rard Le Fur},
  journal={Molecular pharmacology},
  year={1993},
  volume={43 1},
  pages={84-9}
}
Adaptive changes in 5-hydroxytryptamine (5-HT)2 receptors were investigated in mice after repeated administration of SR 46349B, a potent, selective, and competitive 5-HT2 receptor antagonist (Kl = 0.72 +/- 0.05 nM). Repeated administration (twice per day for 3 days and once on the morning of the fourth day) of SR 46349B (5 or 10 mg/kg, orally) caused 24 hr later a marked increase in 5-HT2 receptor number (+41% and +75%, respectively), measured ex vivo in brain cortical membranes with [3H… CONTINUE READING