Repeated Short-term (2h×14d) Emotional Stress Induces Lasting Depression-like Behavior in Mice

  title={Repeated Short-term (2h×14d) Emotional Stress Induces Lasting Depression-like Behavior in Mice},
  author={Kyoung-Shim Kim and Hye-Joo Kwon and In-Sun Baek and Pyung-Lim Han},
  booktitle={Experimental neurobiology},
Chronic behavioral stress is a risk factor for depression. To understand chronic stress effects and the mechanism underlying stress-induced emotional changes, various animals model have been developed. We recently reported that mice treated with restraints for 2 h daily for 14 consecutive days (2h-14d or 2h×14d) show lasting depression-like behavior. Restraint provokes emotional stress in the body, but the nature of stress induced by restraints is presumably more complex than emotional stress… CONTINUE READING


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