Repeated Inescapable Stress Produces a Neuroleptic-like Effect on the Conditioned Avoidance Response

@article{Friedhoff1995RepeatedIS,
  title={Repeated Inescapable Stress Produces a Neuroleptic-like Effect on the Conditioned Avoidance Response},
  author={Arnold J. Friedhoff and Kenneth D Carr and Suzan Uysal and Jack W. Schweitzer},
  journal={Neuropsychopharmacology},
  year={1995},
  volume={13},
  pages={129-138}
}
This study tests the hypothesis that the dopaminergic system mediates a restitutive response by decreasing its own activity in the face of events like persistent inescapable stress that threaten to interrupt organized mental activity. It is well established that neuroleptic drugs inhibit the conditioned avoidance response (CAR), but not the escape response, probably via a reduction in subcortical dopaminergic activity. We trained rats to perform the CAR and then subjected them to acute and… CONTINUE READING