Repeated D1 receptor agonist treatment blocks cocaine-induced locomotor activity and c-fos expression.

Abstract

Pretreatment of rats for 4 days with the selective dopamine D1 receptor agonist A-77636 attenuated the ability of cocaine to induce locomotor hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. Our results suggest that repeated D1 agonist treatment leads to subsensitivity of D1 receptors involved… (More)

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