Repeatability of Quantitative 18F-NaF PET: A Multicenter Study.

  title={Repeatability of Quantitative 18F-NaF PET: A Multicenter Study.},
  author={Christie Lin and Tyler J Bradshaw and Timothy Perk and Stephanie A. Harmon and Jens Eickhoff and Ngoneh Jallow and Peter L. Choyke and William L. Dahut and Steven M. Larson and John L. Humm and Scott B. Perlman and Andrea B. Apolo and Michael J Morris and Glenn X Liu and Robert Jeraj},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={57 12},
18F-NaF, a PET radiotracer of bone turnover, has shown potential as an imaging biomarker for assessing the response of bone metastases to therapy. This study aimed to evaluate the repeatability of 18F-NaF PET-derived SUV imaging metrics in individual bone lesions from patients in a multicenter study. METHODS Thirty-five castration-resistant prostate cancer patients with multiple metastases underwent 2 whole-body (test-retest) 18F-NaF PET/CT scans 3 ± 2 d apart from 1 of 3 imaging sites. A… CONTINUE READING
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