Repeat instability during DNA repair: Insights from model systems.

@article{Usdin2015RepeatID,
  title={Repeat instability during DNA repair: Insights from model systems.},
  author={Karen Usdin and Nealia C. M. House and Catherine H Freudenreich},
  journal={Critical reviews in biochemistry and molecular biology},
  year={2015},
  volume={50 2},
  pages={142-67}
}
The expansion of repeated sequences is the cause of over 30 inherited genetic diseases, including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many spinocerebellar ataxias, and some cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat expansions are dynamic, and disease inheritance and progression are influenced by the size and the rate of expansion. Thus, an understanding of the various cellular mechanisms that cooperate to… CONTINUE READING

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