Repair of the major lesion resulting from C5'-oxidation of DNA.

  title={Repair of the major lesion resulting from C5'-oxidation of DNA.},
  author={Kwan-Young Jung and Tetsuya Kodama and Marc M Greenberg},
  volume={50 28},
Oxidation of the C5'-position of DNA results in direct strand scission. The 3'-fragments produced contain DNA lesions at their 5'-termini. The major DNA lesion contains an aldehyde at its C5'-position, but its nucleobase is unmodified. Excision of the lesion formed from oxidation of thymidine (T-al) is achieved by strand displacement synthesis by DNA polymerase β (Pol β) in the presence or absence of flap endonuclease 1 (FEN1). Pol β displaces T-al and thymidine with comparable efficiency, but… CONTINUE READING


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 45 references

Radiation - Induced Formation of Purine 5 0 , 8 - Cyclonucleosides in Isolated and Cellular DNA : High Stereospeci fi city and Modulating E ff ect of Oxygen

C. Chatgilialoglu, M. Guerra, Q. G. Mulazzani
Org . Biomol . Chem . • 2010

Similar Papers

Loading similar papers…