Repair of the major lesion resulting from C5'-oxidation of DNA.

@article{Jung2011RepairOT,
  title={Repair of the major lesion resulting from C5'-oxidation of DNA.},
  author={Kwan-Young Jung and Tetsuya Kodama and Marc M Greenberg},
  journal={Biochemistry},
  year={2011},
  volume={50 28},
  pages={6273-9}
}
Oxidation of the C5'-position of DNA results in direct strand scission. The 3'-fragments produced contain DNA lesions at their 5'-termini. The major DNA lesion contains an aldehyde at its C5'-position, but its nucleobase is unmodified. Excision of the lesion formed from oxidation of thymidine (T-al) is achieved by strand displacement synthesis by DNA polymerase β (Pol β) in the presence or absence of flap endonuclease 1 (FEN1). Pol β displaces T-al and thymidine with comparable efficiency, but… CONTINUE READING

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Radiation - Induced Formation of Purine 5 0 , 8 - Cyclonucleosides in Isolated and Cellular DNA : High Stereospeci fi city and Modulating E ff ect of Oxygen

C. Chatgilialoglu, M. Guerra, Q. G. Mulazzani
Org . Biomol . Chem . • 2010

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