Repair of products of oxidative DNA base damage in human cells.

@article{Jaruga1996RepairOP,
  title={Repair of products of oxidative DNA base damage in human cells.},
  author={Pawel Jaruga and Miral Dizdaroğlu},
  journal={Nucleic acids research},
  year={1996},
  volume={24 8},
  pages={1389-94}
}
Oxidative DNA damage is the most frequent type of damage encountered by aerobic cells and may play an important role in biological processes such as mutagenesis, carcinogenesis and aging in humans. Oxidative damage generates a myriad of modifications in DNA. We investigated the cellular repair of DNA base damage products in DNA of cultured human lymphoblast cells, which were exposed to oxidative stress by H2O2. This DNA-damaging agent is known to cause base modifications in genomic DNA of… CONTINUE READING
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