Repair of osteochondral defects with autologous chondrocytes seeded onto bioceramic scaffold in sheep.

Abstract

At present, the most popular biomaterials used in cartilage tissue engineering are synthetic polymers. However, problems-such as acidic by-product accumulation and side effects in local or systemic inflammatory reactions during in vivo degradation-are drawing much attention. The polymers are also highly hydrophobic and degrade within 4 weeks, allowing… (More)

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