Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells.

@article{Ledoux1992RepairOM,
  title={Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells.},
  author={Susan P Ledoux and Glenn L. Wilson and E J Beecham and Tinna Stevnsner and Karsten Wassermann and Vilhelm A. Bohr},
  journal={Carcinogenesis},
  year={1992},
  volume={13 11},
  pages={1967-73}
}
Using methodology recently developed to assess gene-specific DNA repair, we have demonstrated that it is possible not only to study mitochondrial DNA repair, but also directly to compare mitochondrial and nuclear DNA repair in the same biological sample. Complex enzymatic mechanisms recognize and repair nuclear DNA damage, but it has long been thought that there was no DNA repair in mitochondria. Therefore, in an attempt to delineate more clearly which DNA repair mechanisms, if any, are… CONTINUE READING

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