Repair of large saddle defects of the mandibular ridge using dual growth factor release-An experimental pilot study in minipigs.

Abstract

AIM To test the hypothesis that the addition of small amounts of rhVEGF to rhBMP2 in a polymer carrier can accomplish equivalent repair effect as a reduced dosage of rhBMP2 compared to rhBMP2 alone. MATERIALS AND METHODS Defects were created bilaterally in the mandibles of 18 minipigs. In 12 test animals, defects were filled with 0.5 g particulate PDLLA/CaCO3 composite loaded with 400 μg rhBMP2/50 μg rhVEGF165 on one side and 800 μg rhBMP2 on the other. After 4 and 13 weeks, the animals were evaluated each for area of new bone formation (mm²) and bone density (area %). RESULTS Area of newly formed bone was higher in defects with carriers loaded with 400 μg rhBMP2 50 µg VEGF165 than in defects with 800 μg rhBMP2 after 4 weeks (11.97 versus 7.97 mm²; p = 0.043) and 13 weeks (72.48 versus 62.2 mm²; p = .028). Defects filled with blank carrier exhibited less bone after 13 weeks (42.75 mm²; p = .039 and .020 respectively). CONCLUSIONS Delivery of rhBMP2 from a polymer carrier can improve repair of large saddle defects of the mandibular ridge. Addition of small amounts of rhVEGF can increase bone formation and at the same time reduce the dosage of rhBMP2.

DOI: 10.1111/jcpe.12739

Cite this paper

@article{Trltzsch2017RepairOL, title={Repair of large saddle defects of the mandibular ridge using dual growth factor release-An experimental pilot study in minipigs.}, author={Markus Tr{\"{o}ltzsch and Alexander Klenke and Petra Santander and Philipp Kauffmann and Matthias Troeltzsch and Anna Rau and Phillip Brockmeyer and Henning Schliephake}, journal={Journal of clinical periodontology}, year={2017}, volume={44 8}, pages={854-863} }