Repair of ionizing radiation-induced DNA damage and risk of second cancer in childhood cancer survivors.

@article{Haddy2014RepairOI,
  title={Repair of ionizing radiation-induced DNA damage and risk of second cancer in childhood cancer survivors.},
  author={Nadia Haddy and Laurence Tartier and Serge Koscielny and Elisabeth Adjadj and Carole Rubino and Laurence Brugi{\`e}res and H{\'e}l{\`e}ne D Pacquement and I Diallo and Florent de Vathaire and Dietrich Averbeck and Janet Hall and Simone Benhamou},
  journal={Carcinogenesis},
  year={2014},
  volume={35 8},
  pages={1745-9}
}
The study's purpose was to assess whether individuals who developed a second malignant neoplasm (SMN) after treatment for a first malignant neoplasm (FMN) had a lower ability to repair DNA double-strand breaks (DSBs) using a bioassay with γH2AX intensity as a surrogate endpoint. In a case-control study nested in a cohort of childhood cancer survivors, lymphoblastoid cell lines (LCLs) were established from blood samples collected from 94 cases (SMN) and 94 matched controls (FMN). LCLs were… CONTINUE READING