Repair of gaps in retroviral DNA integration intermediates.

  title={Repair of gaps in retroviral DNA integration intermediates.},
  author={Kristine E Yoder and Frederic D. Bushman},
  journal={Journal of virology},
  volume={74 23},
Diverse mobile DNA elements are believed to pirate host cell enzymes to complete DNA transfer. Prominent examples are provided by retroviral cDNA integration and transposon insertion. These reactions initially involve the attachment of each element 3' DNA end to staggered sites in the host DNA by element-encoded integrase or transposase enzymes. Unfolding of such intermediates yields DNA gaps at each junction. It has been widely assumed that host DNA repair enzymes complete attachment of the… CONTINUE READING