Repair of full-thickness articular cartilage defects using injectable type II collagen gel embedded with cultured chondrocytes in a rabbit model.

@article{Funayama2008RepairOF,
  title={Repair of full-thickness articular cartilage defects using injectable type II collagen gel embedded with cultured chondrocytes in a rabbit model.},
  author={Atsushi Funayama and Yasuo Niki and Hideo Matsumoto and Shinichi Maeno and Taku Yatabe and Hideo Morioka and Shigeru Yanagimoto and Tetsushi Taguchi and Junzo Tanaka and Yoshiaki Toyama},
  journal={Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association},
  year={2008},
  volume={13 3},
  pages={225-32}
}
BACKGROUND Recently, tissue-engineered chondrocyte transplantation has been tried to treat full-thickness cartilage defects. We developed an injectable type II collagen gel scaffold by chemically reacting type II collagen with polyethylene glycol crosslinker. This type II collagen was prepared from the nasal septa of cattle. In the present study, chondrocytes embedded in type II collagen gel were injected into rabbit full-thickness cartilage defects without a periosteal graft, and the… CONTINUE READING

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