Repair of extensive ionizing-radiation DNA damage at 95 degrees C in the hyperthermophilic archaeon Pyrococcus furiosus.

@article{DiRuggiero1997RepairOE,
  title={Repair of extensive ionizing-radiation DNA damage at 95 degrees C in the hyperthermophilic archaeon Pyrococcus furiosus.},
  author={Jocelyne DiRuggiero and Nick Santangelo and Zeena Nackerdien and Jacques Ravel and Frank T Robb},
  journal={Journal of bacteriology},
  year={1997},
  volume={179 14},
  pages={
          4643-5
        }
}
We investigated the capacity of the hyperthermophile Pyrococcus furiosus for DNA repair by measuring survival at high levels of 60Co gamma-irradiation. The P. furiosus 2-Mb chromosome was fragmented into pieces ranging from 500 kb to shorter than 30 kb at a dose of 2,500 Gy and was fully restored upon incubation at 95 degrees C. We suggest that recombination repair could be an extremely active repair mechanism in P. furiosus and that it might be an important determinant of survival of… CONTINUE READING

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