Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.

Abstract

Ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunits (DNA-PKcs) are members of the phosphatidylinositol 3-like family of serine/threonine kinases that phosphorylate serines or threonines when positioned adjacent to a glutamine residue (SQ/TQ). Both kinases are activated rapidly by DNA double-strand breaks (DSBs) and… (More)
DOI: 10.4049/jimmunol.1101388

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Cite this paper

@article{Gapud2011RepairOC, title={Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.}, author={Eric J. Gapud and Baeck-seung Lee and Grace K. Mahowald and Craig H. Bassing and Barry P Sleckman}, journal={Journal of immunology}, year={2011}, volume={187 4}, pages={1826-34} }