Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

@article{Olsson1980RepairOA,
  title={Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.},
  author={Monica Olsson and T. Lindahl},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 22},
  pages={10569-71}
}
O6-Methylguanine residues disappear from alkylated DNA by an inducible repair process in Escherichia coli. The reaction can be studied in a cell-free system, using DNA treated with a radioactive methylating agent as substrate. The disappearance of labeled O6-methylguanine from DNA is not accompanied by release of radioactive material in an acid-soluble form. Instead, the methyl group of O6-methylguanine appears to be transferred enzymatically to a protein cysteine residue. Radioactively labeled… CONTINUE READING

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