Repair of aflatoxin B1 DNA adducts by the UvrABC endonuclease of Escherichia coli.

@article{Oleykowski1993RepairOA,
  title={Repair of aflatoxin B1 DNA adducts by the UvrABC endonuclease of Escherichia coli.},
  author={Catherine A Oleykowski and J. A. Mayernik and S E Lim and John D. Groopman and Lawrence Grossman and Gerald Norman Wogan and Anthony T. Yeung},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 11},
  pages={
          7990-8002
        }
}
The repair by UvrABC endonuclease of two major adducts formed by aflatoxin B1 in DNA was found to be similar. Aflatoxin epoxide was used to generate the aflatoxin B1.N7-guanine adduct which can convert to aflatoxin B1-formamidopyrimidine adduct. The reaction of the aflatoxin B1 epoxide with DNA follows pseudo-first order kinetics. The DNA sequence-specific relative reactivity of the epoxide is the same as previously observed for aflatoxin B1 activated by liver microsomes, therefore strongly… Expand
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The structural distortions and the less favorable stacking interactions induced by the AFB-α-FAPY adduct explain its lower stability as compared to the AFB-β-Fapy adduct in duplex DNA. Expand
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