Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts.

@article{Asaithamby2008RepairOH,
  title={Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts.},
  author={Aroumougame Asaithamby and Naoya Uematsu and Aloke Chatterjee and Michael D. Story and Sandeep Burma and David J. Chen},
  journal={Radiation research},
  year={2008},
  volume={169 4},
  pages={
          437-46
        }
}
DNA damage generated by high-energy and high-Z (HZE) particles is more skewed toward multiply damaged sites or clustered DNA damage than damage induced by low-linear energy transfer (LET) X and gamma rays. Clustered DNA damage includes abasic sites, base damages and single- (SSBs) and double-strand breaks (DSBs). This complex DNA damage is difficult to repair and may require coordinated recruitment of multiple DNA repair factors. As a consequence of the production of irreparable clustered… CONTINUE READING

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