Repair of DNA lesions associated with triplex-forming oligonucleotides.

  title={Repair of DNA lesions associated with triplex-forming oligonucleotides.},
  author={Joanna Y. Chin and Peter M. Glazer},
  journal={Molecular carcinogenesis},
  volume={48 4},
Triplex-forming oligonucleotides (TFOs) are gene targeting tools that can bind in the major groove of duplex DNA in a sequence-specific manner. When bound to DNA, TFOs can inhibit gene expression, can position DNA-reactive agents to specific locations in the genome, or can induce targeted mutagenesis and recombination. There is evidence that third strand binding, alone or with an associated cross-link, is recognized and metabolized by DNA repair factors, particularly the nucleotide excision… CONTINUE READING

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