Repair and coding properties of 5-hydroxy-5-methylhydantoin nucleosides inserted into DNA oligomers.

@article{Gasparutto2000RepairAC,
  title={Repair and coding properties of 5-hydroxy-5-methylhydantoin nucleosides inserted into DNA oligomers.},
  author={Didier Gasparutto and M Ait-Abbas and Michel Jaquinod and Sergio Boiteux and Jean Cadet},
  journal={Chemical research in toxicology},
  year={2000},
  volume={13 7},
  pages={
          575-84
        }
}
1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-hydroxy-5-methylhydantoin (5-OH-5-Me-dHyd) (3) has been shown to be a major oxidation product of thymidine formed upon exposure of DNA to (*)OH-radical and excited photosensitizers. To investigate the biological and structural significance of the 5-OH-5-Me-dHyd residue to DNA, the latter modified 2'-deoxyribonucleoside was chemically prepared and then site-specifically incorporated into oligodeoxyribonucleotides. This was efficiently achieved using… CONTINUE READING
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