Repair and chromosomal damage.

  title={Repair and chromosomal damage.},
  author={Peter E. Bryant},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  volume={72 3},
  • Peter E. Bryant
  • Published 2004 in
    Radiotherapy and oncology : journal of the…
Chromosomal aberrations in somatic cells link DNA damage with radiation-induced cell killing and individual susceptibility to oncogenesis, and are also potential markers of cancer susceptibility. While there is general acceptance that the DNA double-strand break (DSB) is the principal initiating lesion the complexity of the relationship between the induced frequency and the rates of repair and misjoining of DSB, and the production of chromosome and chromatid aberrations has led to much… CONTINUE READING