Repair-Related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism

Abstract

Thyroid hormone (TH) is important for tissue repair because it regulates cellular differentiation. Intrahepatic TH activity is controlled by both serum TH levels and hepatic deiodinases. TH substrate (T4) is converted into active hormone (T3) by deiodinase 1 (D1) but into inactive hormone (rT3) by deiodinase 3 (D3). Although the relative expressions of D1… (More)
DOI: 10.1210/en.2014-1302

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@inproceedings{Bohinc2014RepairRelatedAO, title={Repair-Related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism}, author={Brittany N. Bohinc and Gregory Alexander Michelotti and Guanhua Xie and Herbert Pang and Ayako Suzuki and Cynthia D. Guy and Dawn Piercy and Leandi Kruger and Marzena Swiderska-syn and Mariana Albuquerque Machado and Thiago Pereira and Ann Marie Zavacki and Manal F. Abdelmalek and Anna Mae Diehl}, booktitle={Endocrinology}, year={2014} }