Reoxygenation and rehypoxiation in the SCCVII mouse tumor.

Abstract

PURPOSE To test the hypothesis that, following preferential killing of tumor hypoxic cells, the fraction of hypoxic cells in the tumor will reestablish itself to pretreatment levels (rehypoxiation) with the same kinetics as for reoxygenation. METHODS AND MATERIALS Mouse squamous cell carcinoma VII (SCCVII) tumors were treated with a single dose of 10 Gy… (More)

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