Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.

@article{Yang2003ReovirusPS,
  title={Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.},
  author={Wen Qing Yang and Donna Lorraine. Senger and Huong Muzik and Zhong Qiao Shi and Denise J. Johnson and Penny M A Brasher and Neill B. Rewcastle and Mark L. Hamilton and Jim Rutka and Johannes Wolff and Cynthia J. Wetmore and Tom Curran and Patrick Wing Kwong Lee and Peter A. J. Forsyth},
  journal={Cancer research},
  year={2003},
  volume={63 12},
  pages={
          3162-72
        }
}
Medulloblastoma (MB), the most common pediatric brain tumor, is a highly malignant disease with a 5-year survival rate of only 60%. Tumor cells invade surrounding tissue and disseminate through cerebral spinal fluid, making treatment difficult. Human reovirus type 3 exploits an activated Ras pathway in tumor cells to support productive infection as an oncolytic virus. Here, we examined the ability of human reovirus to kill MB cells lines and surgical specimens in vitro and inhibit tumor growth… CONTINUE READING

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