Reovirus oncolysis as a novel purging strategy for autologous stem cell transplantation.

@article{Thirukkumaran2003ReovirusOA,
  title={Reovirus oncolysis as a novel purging strategy for autologous stem cell transplantation.},
  author={Chandini M Thirukkumaran and Joanne M. Luider and Douglas A Stewart and Tina Tsz Kwan Cheng and Sasha Michelle Lupichuk and Michael J. Nodwell and J. A. Oliver Russell and Iwona A Auer and Donald G. Morris},
  journal={Blood},
  year={2003},
  volume={102 1},
  pages={
          377-87
        }
}
Hematologic stem cell rescue after high-dose cytotoxic therapy is extensively used for the treatment of many hematopoietic and solid cancers. Gene marking studies suggest that occult tumor cells within the autograft may contribute to clinical relapse. To date purging of autografts contaminated with cancer cells has been unsuccessful. The selective oncolytic property of reovirus against myriad malignant histologies in in vitro, in vivo, and ex vivo systems has been previously demonstrated. In… CONTINUE READING

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