Reovirus as an oncolytic agent against experimental human malignant gliomas.

  title={Reovirus as an oncolytic agent against experimental human malignant gliomas.},
  author={M Elizabeth Wilcox and Woo-ick Yang and Donna L. Senger and N. Barry Rewcastle and Don G. Morris and Penny M A Brasher and Zhong Qiao Shi and Randal N Johnston and Shinsuke Nishikawa and Patrick W. K. Lee and Peter A. Forsyth},
  journal={Journal of the National Cancer Institute},
  volume={93 12},
BACKGROUND Reovirus is a naturally occurring oncolytic virus that usurps activated Ras-signaling pathways of tumor cells for its replication. Ras pathways are activated in most malignant gliomas via upstream signaling by receptor tyrosine kinases. The purpose of this study was to determine the effectiveness of reovirus as an experimental treatment for malignant gliomas. METHODS We investigated whether reovirus would infect and lyse human glioma cell lines in vitro. We also tested the effect… CONTINUE READING
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