Reovirus activates human dendritic cells to promote innate antitumor immunity.

  title={Reovirus activates human dendritic cells to promote innate antitumor immunity.},
  author={Fiona Errington and Lynette P. Steele and Robin J D Prestwich and Kevin J. Harrington and Hardev S. Pandha and Laura Vidal and Johann S de Bono and Peter John Selby and Matthew C. Coffey and Richard G. Vile and Alan A Melcher},
  journal={Journal of immunology},
  volume={180 9},
Oncolytic viruses can exert their antitumor activity via direct oncolysis or activation of antitumor immunity. Although reovirus is currently under clinical investigation for the treatment of localized or disseminated cancer, any potential immune contribution to its efficacy has not been addressed. This is the first study to investigate the ability of reovirus to activate human dendritic cells (DC), key regulators of both innate and adaptive immune responses. Reovirus induced DC maturation and… CONTINUE READING


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