Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.

@article{Yannelli1986ReorientationAF,
  title={Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.},
  author={John R. Yannelli and James A. Sullivan and Gerald L Mandell and Victor H Engelhard},
  journal={Journal of immunology},
  year={1986},
  volume={136 2},
  pages={
          377-82
        }
}
The interaction of murine cytotoxic T lymphocyte (CTL) clones with human lymphoblastoid target cells was studied in thin preparations by using high resolution cinemicrography. CTL not bound to target cells were morphologically polar, possessing a broad leading edge containing the nucleus, and a tapered tail containing a large number of granules. The CTL were observed to move by the extension of pseudopods from the leading edge. Initial contact with a target cell was made via the leading edge of… CONTINUE READING
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