Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion. Role of the extracellular matrix.

@article{Deller2000ReorganizationOT,
  title={Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion. Role of the extracellular matrix.},
  author={Thomas Deller and Carola A Haas and Michael Frotscher},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={911},
  pages={207-20}
}
Entorhinal cortex lesion (ECL) partially denervates the fascia dentata of the hippocampus. This is said to induce the sprouting of intact fibers from neighboring layers that invade the zone of the degenerating axons. However, recent studies using anterograde tracing failed to demonstrate sprouting across laminar boundaries. Sprouting does occur, but it mainly involves unlesioned fiber systems terminating within the layer of fiber degeneration. It is now of interest to identify the cues that… CONTINUE READING
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