Reorganization of the rat cerebellar cortex during postnatal development following cisplatin treatment.

@article{Avella2006ReorganizationOT,
  title={Reorganization of the rat cerebellar cortex during postnatal development following cisplatin treatment.},
  author={Debora Avella and Maria Bonaria Pisu and Elisa Roda and Marta Gravati and G. L. Bernocchi},
  journal={Experimental neurology},
  year={2006},
  volume={201 1},
  pages={131-43}
}
We examined the effects of the antitumor agent cisplatin on the development and plasticity of cerebellar cytoarchitecture. Since knowledge of the parallel and climbing fiber-Purkinje cell system is important in order to determine the architectural basis of cerebellar function, we used immunofluorescence for vesicular glutamate transporters (VGluT1 and VGluT2) to evaluate the trend of synaptogenesis of parallel and climbing fibers on Purkinje cells in the cerebellum vermis after a single… CONTINUE READING