Reorganization of enhancer patterns in transition from naive to primed pluripotency.

@article{Buecker2014ReorganizationOE,
  title={Reorganization of enhancer patterns in transition from naive to primed pluripotency.},
  author={Christa Buecker and Rajini Srinivasan and Zhixiang Wu and Eliezer Calo and Dario Acampora and Tiago Faial and Antonio Simeone and Minjia Tan and Tomek Swigut and Joanna Wysocka},
  journal={Cell stem cell},
  year={2014},
  volume={14 6},
  pages={
          838-53
        }
}
Naive and primed pluripotency is characterized by distinct signaling requirements, transcriptomes, and developmental properties, but both cellular states share key transcriptional regulators: Oct4, Sox2, and Nanog. Here, we demonstrate that transition between these two pluripotent states is associated with widespread Oct4 relocalization, mirrored by global rearrangement of enhancer chromatin landscapes. Our genomic and biochemical analyses identified candidate mediators of primed state-specific… Expand
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TLDR
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