Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction.

@article{Tsai2005ReorganizationOC,
  title={Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction.},
  author={J C Tsai and Chia-Lun Wu and H J Chien and Chin-Tin Chen},
  journal={Lasers in surgery and medicine},
  year={2005},
  volume={36 5},
  pages={398-408}
}
BACKGROUND AND OBJECTIVES This study investigated the early cellular events which occurred after mitochondrial photodamage induced by 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT). STUDY DESIGN/MATERIALS AND METHODS Subcellular localization of protoporphyrin IX (PpIX) in NIH3T3 cells was studied by confocal microscopy. Mitochondrial damage was assessed by measuring mitochondrial transmembrane potential and ATP contents, and confirmed by characteristic appearance on… CONTINUE READING

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