Reorganization of chromosome architecture in replicative cellular senescence

@article{Criscione2016ReorganizationOC,
  title={Reorganization of chromosome architecture in replicative cellular senescence},
  author={Steven W. Criscione and Marco De Cecco and Benjamin Siranosian and Yue Zhang and Jill A Kreiling and John M. Sedivy and Nicola Neretti},
  journal={Science Advances},
  year={2016},
  volume={2}
}
Replicative cellular senescence is a fundamental biological process characterized by an irreversible arrest of proliferation. Senescent cells accumulate a variety of epigenetic changes, but the three-dimensional (3D) organization of their chromatin is not known. We applied a combination of whole-genome chromosome conformation capture (Hi-C), fluorescence in situ hybridization, and in silico modeling methods to characterize the 3D architecture of interphase chromosomes in proliferating… CONTINUE READING
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