Reorganization of actin filaments enhances chondrogenic differentiation of cells derived from murine embryonic stem cells.

@article{Zhang2006ReorganizationOA,
  title={Reorganization of actin filaments enhances chondrogenic differentiation of cells derived from murine embryonic stem cells.},
  author={Zijun Zhang and Joseph M Messana and Nathaniel S Hwang and Jennifer H Elisseeff},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={348 2},
  pages={
          421-7
        }
}
Differentiation of embryonic stem cells is of great interest to developmental biology and regenerative medicine. This study investigated the effects of cytochalasin D (CD) on the distribution of actin filaments in mouse embryoid body (EB)-derived cells. Furthermore, CD was applied to chondrogenic medium to examine its chondrogenic effect. CD at a concentration of 1 microg/ml disrupted stress fibers in EB-derived cells. Actin filaments in treated cells reorganized into a peripheral pattern, and… CONTINUE READING

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