Reorganization of Functional Connectivity of the Language Network in Patients with Brain Gliomas

@article{Briganti2012ReorganizationOF,
  title={Reorganization of Functional Connectivity of the Language Network in Patients with Brain Gliomas},
  author={Chiara Briganti and Carlo Sestieri and Peter A Mattei and Romina Esposito and Renato Juan Galzio and Armando Tartaro and Gian Luca Romani and Massimo Caulo},
  journal={American Journal of Neuroradiology},
  year={2012},
  volume={33},
  pages={1983 - 1990}
}
BACKGROUND AND PURPOSE: fcMRI measures spontaneous and synchronous fluctuations of BOLD signal between spatially remote brain regions. The present study investigated potential LN fcMRI modifications induced by left hemisphere brain gliomas. MATERIALS AND METHODS: We retrospectively evaluated fcMRI in 39 right-handed patients with a left hemisphere brain glioma and 13 healthy controls. Patients and controls performed a verb-generation task to identify individual BOLD activity in the left IFG… 
The Functional Reorganization of Language Network Modules in Glioma Patients: New Insights From Resting State fMRI Study
TLDR
Preoperative evaluation of changes in LN caused by gliomas could provide the surgeon a reference to optimize resection while maintaining functional balance, and emphasize the importance of considering the modulatory effects of core-periphery mechanisms from a network perspective.
Left frontal glioma induces functional connectivity changes in syntax-related networks
TLDR
The results indicate that these pathways are most crucial among the syntax-related networks among patients with a left frontal glioma, and both data from the activation patterns and functional connectivity should be combined to assess any behavioral deficits associated with brain abnormalities.
The Temporal Pattern of a Lesion Modulates the Functional Network Topology of Remote Brain Regions
TLDR
There is a lower capacity for local, specialized information processing coupled to a higher capacity for distributed information processing in LGG patients, which underline the utility of a network perspective in evaluating effects of focal brain injury.
Presurgical localization and spatial shift of resting state networks in patients with brain metastases
TLDR
Evidence is provided that ICA is a promising approach for presurgical localization of multiple RSNs from resting-state functional MRI data in individual patients and more attention should be paid to the spatial shifts of the R SNs before surgical resection.
Lesion-Specific Language Network Alterations in Temporal Lobe Epilepsy
TLDR
Network analysis allows new insights into language organization and provides possible imaging biomarkers for language function and the importance of a personalized treatment strategy in patients with epilepsy.
Disrupted functional connectivity affects resting state based language lateralization
Motor Network Plasticity and Low-Frequency Oscillations Abnormalities in Patients with Brain Gliomas: A Functional MRI Study
TLDR
A comparison of the two approaches indicated that power spectral analysis is more sensitive than functional connectivity analysis for identifying the neurological abnormalities underlying motor function plasticity induced by slow-growing tumors.
Functional Language Shift to the Right Hemisphere in Patients with Language-Eloquent Brain Tumors
TLDR
This is the first study that shows by means of an anatomically accurate virtual lesion model that a shift of language function to the non-dominant hemisphere can occur.
Functional Brain Areas Mapping in Patients with Glioma Based on Resting-State fMRI Data Decomposition
In current work we propose a three-step approach to automatic and efficient functional brain areas mapping as well demonstrate in case studies on three patients with gliomas the potential
Structural and Functional Reorganization Within Cognitive Control Network Associated With Protection of Executive Function in Patients With Unilateral Frontal Gliomas
TLDR
Tumors invading the frontal lobe induced contralesional structural and functional reorganization within the posterior CCN in patients with unilateral frontal gliomas, which suggests that the contralsional superior parietal cortex acts as a functional compensation hub within the CCN, which may protect it against the detrimental effects of tumor invasion on executive functions.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
Functional Connectivity MR Imaging of the Language Network in Patients with Drug-Resistant Epilepsy
TLDR
In patients with intractable epilepsy, FC-MRI revealed an overall reduction and reorganization of the connectivity pattern within the language network, which was positively correlated with linguistic performance only in patients with LE.
Mapping functionally related regions of brain with functional connectivity MR imaging.
TLDR
This work tested the hypothesis that fcMRI maps, based on the synchrony of low-frequency blood flow fluctuations, identify brain regions that show activation on fMRI maps of sensorimotor, visual, language, and auditory tasks.
Plasticity of language networks in patients with brain tumors: A positron emission tomography activation study
TLDR
Two compensatory mechanisms in patients with slowly evolving brain lesions are described: An intrahemispheric mechanism with recruitment of left frontolateral regions other than classic language areas; and an interhemispherical compensatory mechanism with frontol lateral activation in the nondominant hemisphere, supporting the hypothesis that right frontolilateral activations are a disinhibition phenomenon.
Comparison of Hypothesis- and a Novel Hybrid Data/Hypothesis-Driven Method of Functional MR Imaging Analysis in Patients with Brain Gliomas
TLDR
The use of the ICA-GLM is suggested as a valid alternative to the classic GLM method for presurgical mapping in patients with brain tumors and to replicate the present results in a broader sample of patients.
Functional connectivity in the human language system: a cortico-cortical evoked potential study.
TLDR
The present study revealed a bidirectional connection between Broca's and Wernicke's areas probably through the arcuate fasciculus and/or the cortico-subcortico-cortical pathway, which suggests that perisylvian and extrasylVian language areas participate in the language system as components of a network by means of feed-forward and feed-back projections.
Modeling the Impact of Lesions in the Human Brain
TLDR
The model suggests that dynamic lesion effects can be predicted on the basis of specific network measures of structural brain networks and that these effects may be related to known behavioral and cognitive consequences of brain lesions.
Detection of functional connectivity using temporal correlations in MR images
TLDR
The proposed methodology can reveal the presence and strength of functional connections in high‐level cognitive systems, as illustrated by application to the language system.
Human Brain Language Areas Identified by Functional Magnetic Resonance Imaging
TLDR
Although partly in conflict with the classical model of language localization, FMRI findings are generally compatible with reported lesion data and provide additional support for ongoing efforts to refine and extend the classicalmodel.
...
1
2
3
4
5
...