Renovascular hypertension leads to DNA damage and apoptosis in bone marrow cells.

@article{Campagnaro2013RenovascularHL,
  title={Renovascular hypertension leads to DNA damage and apoptosis in bone marrow cells.},
  author={Bianca P Campagnaro and Clarissa Loureiro Tonini and Luciano M Doche and Breno Valentim Nogueira and Elisardo Corral Vasquez and Silvana dos Santos Meyrelles},
  journal={DNA and cell biology},
  year={2013},
  volume={32 8},
  pages={458-66}
}
Angiotensin II (Ang II), which plays a pivotal role in the pathophysiology of the two-kidney, one-clip (2K1C) Goldblatt hypertension, has been associated with augmented generation of reactive oxygen species (ROS) in some cells and tissues. In the present study, we evaluated the influence of 2K1C hypertension on oxidative stress, DNA fragmentation, and apoptosis of bone marrow (BM) cells. Two weeks after the renal artery clipping or Sham operation, flow cytometry analysis showed a higher… CONTINUE READING
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