Renoprotective effects of felodipine and/or enalapril in spontaneously hypertensive rats with and without L-NAME.

@article{Francischetti1998RenoprotectiveEO,
  title={Renoprotective effects of felodipine and/or enalapril in spontaneously hypertensive rats with and without L-NAME.},
  author={Alo{\'i}sio Francischetti and Hidehiko Ono and Edward David Frohlich},
  journal={Hypertension},
  year={1998},
  volume={31 3},
  pages={
          795-801
        }
}
To determine the renoprotective effects of a calcium antagonist (felodipine) and an angiotensin-converting enzyme (ACE) inhibitor (enalapril), alone or in combination, 10 groups of 19-week-old spontaneously hypertensive rats (SHR) (with or without N(G)-nitro-L-arginine methyl ester [L-NAME]) were studied using renal micropuncture techniques. Group 1 (control), group 2 (felodipine, 30 mg x kg(-1) x d[-1]), group 3 (enalapril, 30 mg x kg(-1) x d[-1]), and group 4 (felodipine plus enalapril, 15 mg… CONTINUE READING
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