Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes.

  title={Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes.},
  author={Sik Lee and Won Kim and S O Moon and Mi Jeong Sung and Duk Hoon Kim and Kyung Pyo Kang and Kyu Yoon Jang and Sang Yong Lee and Byung Hyun Park and Gou Young Koh and Sung Kwang Park},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={22 2},
BACKGROUND Inflammatory processes have been recently seen as underlying the pathogenesis of diabetic nephropathy. Angiopoietin-1 (Ang1) plays essential roles in regulating vascular growth, development, maturation, permeability and inflammation. We have developed a soluble, stable and potent Ang1 variant, cartilage oligomeric matrix protein (COMP)-Ang1. METHODS In this study, db/db mice were treated with recombinant adenovirus expressing either COMP-Ang1 or LacZ. Histology, inflammatory… CONTINUE READING