Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide.

@article{Villamil2007ReninIW,
  title={Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide.},
  author={Alberto S Villamil and Steven G Chrysant and David H. Calhoun and Bonnie Schober and Huang Cheng Hsu and Linda Matrisciano-Dimichino and Jack Fan Zhang},
  journal={Journal of hypertension},
  year={2007},
  volume={25 1},
  pages={217-26}
}
OBJECTIVES Aliskiren is a novel, orally active renin inhibitor. Its antihypertensive efficacy and safety, alone and in combination with hydrochlorothiazide (HCTZ), were investigated in an 8-week, double-blind, placebo-controlled trial in hypertensive patients. The effects of these treatments on plasma renin activity (PRA) were also assessed. METHODS A total of 2776 patients aged >or=18 years with mean sitting diastolic blood pressure (MSDBP) 95-109 mmHg were randomized to receive once-daily… CONTINUE READING