Renin inhibition and atherosclerosis.

  • F. Luft
  • Published 2008 in
    Nephrology, dialysis, transplantation : official…

Abstract

Angiotensin II (Ang II) has long been considered the major bioactive effector molecule of the renin–angiotensin system and is recognized as a major contributor to hypercholesterolaemia-induced atherosclerosis [1,2]. LDLreceptor-deficient and apoE-deficient mice have been intensively investigated in this regard. Chronic Ang II infusions in such mice… (More)
DOI: 10.1093/ndt/gfn184

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